Celiac disease (CD) is an autoimmune disorder of the small intestine and other organs in genetically predisposed people who consume dietary gluten. The disorder is caused by genetic and non-genetic factors. About 1 in 3 people who become sensitive to gluten are at risk for CD due to the celiac-associated genes they inherit – CD runs in families. Other factors influencing risk include gluten consumption, family history, and pre-existing autoimmune disorders such as rheumatoid arthritis and Sjogren’s syndrome.
GlutenID® tests all common gene variant combinations associated with increased risk of developing celiac disease. If none of these variants are detected the negative predictive value (NPV) for development or presence of celiac disease is > 99%.
Classic
Diarrhea, gas, bloating
Poor appetite and weight loss
Non-classic (More common than classic symptoms)
Skin rashes (dermatitis herpetiformis) and hair loss
Anemia
Thyroid disease
Brain fog; depression
Infertility
Hepatitis
Treatment
Celiac disease can be cured and prevented with a gluten free diet in genetically susceptible individuals.
GlutenID® Test performance for celiac genetic health risk
Accuracy was determined to be 100% comparing NGS results with bi-directional Sanger sequencing.
TIMELINE
Celiac disease is believed to have developed over 8,000 years ago when hunter/gatherers began encountering new types of food (including wheat) during the neolithic period agricultural revolution. However it wasn’t until the first century AD that a Greek physician named Aretaeus of Cappadocia identified the symptoms as a disease of the “koelia” or abdomen in Greek. Before the true trigger for celiac disease was identified many treatments and diets were tried, including strict rice, mussel, and even banana diets. It wasn’t until the 1970s-1990s that celiac disease was recognized as an autoimmune disease and genes were pinpointed.
First Century AD Greek physician who identified celiac disease.
CeliacDxTM is the only testing strategy incorporating all diagnostic criteria: antibodies, small bowel biopsy, and genetics into a single comprehensive report. Although small bowel biopsy has long been considered “The Gold Standard” for celiac disease diagnosis, the other two components (antibodies and genetics) are equally critical for accurate diagnosis.
The CeliacDx pathology consultation incorporates results from all three diagnostic tests: antibodies, biopsy, genetics into a single POSITVE or NEGATIVE diagnosis for celiac disease. If all three tests have already been performed but the celiac disease diagnosis is still unresolved, just enclose the test reports in the kit instead of samples. Our pathologists will evaluate the results and issue an actionable diagnosis. Take a closer look at the report here.
An accurate celiac disease diagnosis is delayed on average by 6 to 10 years. Delayed diagnoses often lead to worsening health conditions. CeliacDx significantly reduces the time to diagnosis by combining the three gold standard tests to provide comprehensive reporting of your celiac disease subtype.
CASE EXAMPLE
For a patient with celiac disease symptoms, positive family history, negative antibody test results and positive biopsy, use CeliacDx for resolution of positive versus negative celiac disease diagnosis.
