GLUTEN ID®

Celiac Disease and GlutenID®

Celiac Disease Genetic Health Risk

Celiac disease (CD) is an autoimmune disorder of the small intestine and other organs in genetically predisposed people who consume dietary gluten. The disorder is caused by genetic and non-genetic factors. About 1 in 3 people who become sensitive to gluten are at risk for CD due to the celiac-associated genes they inherit – CD runs in families. Other factors influencing risk include gluten consumption, family history, and pre-existing autoimmune disorders such as rheumatoid arthritis and Sjogren’s syndrome.

GlutenID tests all common gene variant combinations associated with increased risk of developing celiac disease. If none of these variants are detected the negative predictive value (NPV) for development or presence of celiac disease is > 99%.

Typical Signs and Symptoms

Classic

Diarrhea, gas, bloating
Poor appetite and weight loss

Non-classic (More common than classic symptoms)

Skin rashes (dermatitis herpetiformis) and hair loss
Anemia
Thyroid disease
Brain fog; depression
Infertility
Hepatitis

Treatment

Celiac disease can be cured and prevented with a gluten free diet in genetically susceptible individuals.

GlutenID Test performance for celiac genetic health risk

Accuracy was determined to be 100% comparing NGS results with bi-directional Sanger sequencing.

TIMELINE

Celiac History

Celiac disease is believed to have developed over 8,000 years ago when hunter/gatherers began encountering new types of food (including wheat) during the neolithic period agricultural revolution. However it wasn’t until the first century AD that a Greek physician named Aretaeus of Cappadocia identified the symptoms as a disease of the “koelia” or abdomen in Greek. Before the true trigger for celiac disease was identified many treatments and diets were tried, including strict rice, mussel, and even banana diets. It wasn’t until the 1970s-1990s that celiac disease was recognized as an autoimmune disease and genes were pinpointed.

Aretaeus of Cappadocia

First Century AD Greek physician who identified celiac disease.

Woman has celiac disease genes and damage.
50AD
Philosopher Blaise Pascal is believed by some to have suffered from celiac disease.
1800s
Dr. Samuel Gee writes the first modern medical description of celiac disease and hypothesizes it can be treated through diet.
1924
Dr. Willem Dicke theorizes that wheat is triggering celiac disease and develops a wheat-free diet to treat celiac disease patients.
1952
Dr. Margot Shiner performs the first oral biopsy on a child with celiac disease.
1970s-1990s
First potential drugs for celiac disease begin the clinical trial process.
First Century AD
Aretaeus of Cappadocia writes the first medical description of celiac disease.
1600s
Matthew Baillie describes a diarrheal disorder that improves on a rice-based diet.
1887
Dr. Sindey Haas treats children with celiac disease with his banana diet.
1940s
Medical team publishes their findings about wheat, rye, flour, and celiac disease.
1956
Celiac disease is recognized as an autoimmune disease, and genes are pinpointed.
2006

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