Frequently Asked Questions

OBTAINING A KIT AND MAILING YOUR SAMPLE

You can order a Gluten ID test kit online through our SHOP or obtain your kit from one of our physician partners: Huebner Family Medicine or O3 PLUS, LLC

No, a blood sample is not necessary for Gluten ID testing. Instead, cheek cells collected from inside your mouth are used to obtain a DNA sample.

Our kits contain two swabs in transport tubes and instructions for how to collect the cheek cells from inside both sides of your mouth.

No. The Gluten ID tests DNA which is unaffected by what you have eaten before the test. The only thing not to do is eat at the same time you are swabbing the inside of your mouth as food could interfere with sample collection.

Any time of day or night is fine for collecting cheek cell samples.

It is preferable to send samples to the laboratory as soon as they are collected.

No, the swab samples are stable at room temperature for several days without affecting DNA collection.

A prepaid USPS mailing envelope is included in every kit. Simply place your swab tubes back in the Gluten ID kit and put them in a United States Postal Service Collection Box.

NOTE: FedEx and UPS will not deliver USPS samples so do not drop off your kit with either of these carriers.

RECEIVING AND UNDERTANDING YOUR RESULTS

PacificDx, a College of American Pathologists (CAP) accredited laboratory in Irvine, CA is the only laboratory certified to run the Gluten ID test.

Results are sent via email to you and/or your doctor via the email address you provided when registering your kit.

Approximately 1% of samples do not yield DNA of sufficient quality/quantity for testing. In these cases a new kit is provided free of charge. If a second sample fails, you will receive a refund.

WHAT IF I HAVE POSITIVE RESULTS

Positive results mean you have inherited DQ2 and/or DQ8 genes from one or both parents and can potentially transmit them to future generations.

Having DQ2 and/or DQ8 genes is not diagnostic of celiac disease. However, these findings indicate your immune system has the capability to recognize gluten proteins and mount an abnormal immune response against your own tissue.

If a symptomatic individual on a gluten containing diet tests positive for celiac-associated genes, the best confirmatory test is tissue transglutanimase (tTG) antibody testing. However, this test will only be positive if adequate gluten has been consumed prior to testing. If your doctor wants you to have your blood tested for tTG antibodies do not go on a gluten-free diet until after your antibodies are tested.

Your doctor will order tissue transglutanimase (tTG) testing to confirm your diagnosis.

WHAT IF I HAVE NEGATIVE RESULTS

NEGATIVE results mean you have not inherited the celiac-associated genes DQ2 or DQ8 and you have < 1% chance of developing full blown celiac disease of the small bowel. If you are the first degree family member of an individual with celiac disease, you can discontinue tTG screening  and small bowel biopsies.

You may be suffering from a gluten allergy or non-celiac gluten sensitivity. Both of these conditions can produce symptoms similar to celiac associated gluten intolerance, but because you do no carry the DQ2 or DQ8 genes you are at < 1% risk for developing celiac disease. If you are still searching for the root cause of your symptoms you can learn more at the AAAA&I: https://www.aaaai.org/conditions-and-treatments/library/allergy-library/celiac-disease

HOW DOES GLUTEN ID DIFFER FROM OTHER GENETIC TESTS?

Gluten ID covers all of the celiac-associated DNA markers which include HLA-DQ2.2, DQ8, DQ2.5, and DQ7. The personal genetic services tests may not cover all these markers. As you have already tested positive for one of the markers, you are at some level of risk (low, moderated, elevated) for development of celiac disease. Gluten ID looks more deeply at your celiac genetics and reports your results as a spectrum of risk instead of giving you binary positive/negative results.

Other benefits of Gluten ID testing include:

  • A reporting format designed to share with your doctor and become part of your medical record.
  • Actionable next steps including follow up testing and dietary gluten recommendations.