What Your Genes Can Tell You About Celiac Disease Risk

Celiac disease is a serious autoimmune disorder triggered by the ingestion of gluten, a protein found in wheat, barley, and rye. While it affects approximately 1 in 100 people globally, many cases remain undiagnosed due to its diverse symptoms and complex diagnostic process. Genetics play a pivotal role in determining an individual’s susceptibility to celiac disease, and recent advancements now make it possible to assess this risk through precise genetic testing.

Understanding the Genetic Link to Celiac Disease

Celiac disease is strongly associated with specific genetic markers—particularly the HLA-DQ2 and HLA-DQ8 haplotypes located within the HLA-DQA1 and HLA-DQB1 genes. Approximately 95% of people with celiac disease carry the HLA-DQ2 variant, while most of the remaining individuals carry HLA-DQ8. However, having these genes does not mean you will definitely develop the disease—it only indicates a genetic predisposition.

What Are GlutenIDs?

Targeted-Genomics’ GlutenID Celiac Disease Home Test analyzes key variants in the HLA-DQA1 and HLA-DQB1 genes to identify specific combinations, or “GlutenIDs,” that correspond to varying levels of celiac disease risk. These GlutenIDs allow for a more nuanced understanding of your genetic predisposition:

• High Risk: Presence of both copies of HLA-DQ2 or DQ8
• Moderate Risk: One copy of HLA-DQ2 or DQ8
• Low/No Risk: Absence of both haplotypes

This stratified risk model aids in early screening and prevention strategies, particularly for individuals with a family history of celiac disease.

Why Genetic Testing Matters

Many celiac symptoms—such as bloating, fatigue, anemia, and joint pain—are nonspecific and can overlap with other conditions like IBS or lactose intolerance. Genetic testing helps:

• Rule out celiac disease if no risk alleles are present
• Identify high-risk individuals for closer clinical monitoring
• Guide further testing, such as serology or intestinal biopsy, in symptomatic individuals

Since HLA-DQ genotyping remains stable throughout life, a single test provides lifelong insights.

Who Should Consider Genetic Testing?

Genetic testing is especially valuable for:

• First-degree relatives of celiac patients
• Individuals with unexplained gastrointestinal symptoms
• People diagnosed with autoimmune diseases (e.g., type 1 diabetes, thyroiditis)
• Those starting a gluten-free diet before traditional diagnostic workup

The GlutenID test offers a convenient, non-invasive saliva-based method to assess genetic risk from the comfort of home.

How GlutenID Works

1. Order Online: Purchase the test directly from Targeted-Genomics
2. Collect Sample: Use the provided kit to collect a saliva sample
3. Send Back: Mail it to the certified lab using prepaid shipping
4. Receive Results: View your personalized risk report securely online

Your report includes a breakdown of your HLA-DQ status, your corresponding GlutenID, and actionable insights to discuss with your healthcare provider.

Real-World Impact: A Case Example

Consider Jane, a 35-year-old with persistent digestive issues and a mother with diagnosed celiac disease. Before committing to a gluten-free diet, she used the GlutenID test and discovered she carried both HLA-DQ2 alleles, placing her at high genetic risk. Her physician then ordered confirmatory blood tests and biopsy, leading to a formal diagnosis. Early intervention helped Jane manage her symptoms more effectively and prevent further intestinal damage.

Genetics Isn’t Destiny—But It’s a Powerful Clue

While genetics alone can’t diagnose celiac disease, they form a crucial piece of the diagnostic puzzle. Knowing your GlutenID empowers you and your physician to take proactive steps toward better health.

Take Control of Your Health

If you or a loved one are experiencing symptoms or have a family history of celiac disease, consider starting with a genetic test. The GlutenID Celiac Disease Home Test offers a scientifically validated, user-friendly way to understand your genetic predisposition.

Shop now and take the first step toward clarity and control.