How a Saliva Test Can Reveal Your Genetic Risk for Celiac Disease

Celiac disease is an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine. While environmental factors play a role, genetics significantly influence an individual’s susceptibility. Understanding one’s genetic predisposition can be a pivotal step in proactive health management.

The Genetic Underpinnings of Celiac Disease

Research has identified specific human leukocyte antigen (HLA) genes—particularly HLA-DQ2 and HLA-DQ8—as primary genetic markers associated with celiac disease. Approximately 95% of individuals with celiac disease possess the HLA-DQ2 variant, while most of the remainder carry HLA-DQ8. However, possessing these genes doesn’t guarantee disease development; it merely indicates a heightened risk.

Introducing the GlutenID® Celiac Genetic Home Test

Targeted Genomics offers the GlutenID® Celiac Genetic Home Test, a non-invasive, saliva-based test designed to identify genetic markers associated with celiac disease. Utilizing qualitative genotyping, the test analyzes variants in the HLA-DQA1 and HLA-DQB1 genes to detect haplotypes linked to varying levels of celiac disease risk. Notably, the GlutenID® test has received FDA clearance, underscoring its reliability and accuracy.

The Testing Process: Simple and Convenient

1. Order the Kit: Purchase the GlutenID® test kit directly from Targeted Genomics.

2. Collect Your Sample: Use the provided ORAcollectDx saliva collection device to collect your sample.

3. Send It In: Mail your sample to the certified laboratory using the prepaid envelope included in the kit.

4. Receive Results: Access your personalized risk report securely online.

The entire process is designed for ease and privacy, eliminating the need for blood draws or clinic visits.

Interpreting Your Results

The GlutenID® test categorizes results into a spectrum of risk levels based on detected haplotypes:

• Increased Risk: Presence of high-risk haplotypes like DQ2.5/DQ2.5 or DQ2.5/DQ8.

• Low Risk: Presence of haplotypes such as DQ8/DQ8 or DQ8/DQ7.

• Not Likely At Risk: Absence of risk-associated haplotypes, indicating a less than 1% chance of developing celiac disease.

Understanding your genetic risk can inform decisions about further diagnostic testing or dietary adjustments.

Why Choose Genetic Testing?

• Early Detection: Identify risk before symptoms manifest.

• Family Planning: Understand potential genetic risks for offspring.

• Informed Decisions: Make proactive lifestyle and dietary choices.

• Peace of Mind: Rule out genetic predisposition with high accuracy.

Genetic testing serves as a valuable tool in the comprehensive assessment of celiac disease risk, especially for individuals with a family history or related autoimmune conditions.

Take the First Step Towards Informed Health

Empower yourself with knowledge about your genetic risk for celiac disease. The GlutenID® Celiac Genetic Home Test offers a reliable, convenient, and non-invasive method to gain insights into your health.

Order your GlutenID® test kit today and take a proactive step towards understanding your health.