High Resolution (Hi-Res) HER2 Testing for HER2 Equivocal Breast Cancer

Knowing the HER2 (ERBB2) status in newly diagnosed breast cancer is critical for selecting patients predicted to respond to anti-HER2 therapy.

The College of American Pathologists (CAP)/American Society for Clinical Oncology (ASCO) guidelines recommend all newly diagnosed and metastatic breast tumors be evaluated for HER2 positivity by protein-based immunohistochemistry (IHC) and/or chromosome-based fluorescence in situhybridization (FISH) .

In the majority of cases, these tests provide a clearly actionable “positive” or “negative” answer.

However, in an estimated 10- to 20% of breast cancers the tumor’s true HER2 status remains a mystery because both tests are reported as “equivocal.”

“Double equivocal” breast cancer presents a treatment decision dilemma for oncologists and the clinical need for an alternative testing method to deliver unequivocal results.

The Hi-Res HER2 test is designed to meet the needs of oncologists and their patients with “high-risk, HER2 equivocal breast cancer.”

Drawing from over 10 years experience in resolving “double equivocal” breast cancer, the Hi-Res HER2 test was developed by Targeted Genomics and optimized in the PacificDxLaboratory, Irvine CA to provide the answers clinicians and patients are looking for.

Hi-Res HER2 uses DNA microarray to provide:

• Definitive results for HER2 gene status.
• Results from formalin fixed paraffin embedded (FFPE) tissue.
• Fast turn around time
• Testing billable to insurance

For Hi-Res HER2 consultations please contact Precision Pathology Client Services: 210-646-0890.
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