GlutenID Explained: The Science Behind Genetic Celiac Testing

Celiac disease is an autoimmune disorder triggered by the ingestion of gluten, a protein found in wheat, barley, and rye. While environmental factors play a role, genetics significantly influence an individual’s susceptibility. Understanding one’s genetic predisposition can be a pivotal step in proactive health management.

The Genetic Basis of Celiac Disease

Research has identified specific human leukocyte antigen (HLA) genes—particularly HLA-DQ2 and HLA-DQ8—as primary genetic markers associated with celiac disease. Approximately 95% of individuals with celiac disease possess the HLA-DQ2 variant, while most of the remainder carry HLA-DQ8. However, possessing these genes doesn’t guarantee disease development; it merely indicates a heightened risk.

Introducing the GlutenID® Celiac Genetic Home Test

Targeted Genomics offers the GlutenID® Celiac Genetic Home Test, a non-invasive, saliva-based test designed to identify genetic markers associated with celiac disease. Utilizing qualitative genotyping, the test analyzes variants in the HLA-DQA1 and HLA-DQB1 genes to detect haplotypes linked to varying levels of celiac disease risk. Notably, the GlutenID® test has received FDA clearance, underscoring its reliability and accuracy.

The Testing Process: Simple and Convenient

1. Order the Kit: Purchase the GlutenID® test kit directly from Targeted Genomics.

2. Collect Your Sample: Use the provided ORAcollectDx saliva collection device to collect your sample.

3. Send It In: Mail your sample to the certified laboratory using the prepaid envelope included in the kit.

4. Receive Results: Access your personalized risk report securely online.

The entire process is designed for ease and privacy, eliminating the need for blood draws or clinic visits.

Interpreting Your Results

The GlutenID® test categorizes results into a spectrum of risk levels based on detected haplotypes:

• Increased Risk: Presence of high-risk haplotypes like DQ2.5/DQ2.5 or DQ2.5/DQ8.

• Low Risk: Presence of haplotypes such as DQ8/DQ8 or DQ8/DQ7.

• Not Likely At Risk: Absence of risk-associated haplotypes, indicating a less than 1% chance of developing celiac disease.

Understanding your genetic risk can inform decisions about further diagnostic testing or dietary adjustments.

Why Choose Genetic Testing?

• Early Detection: Identify risk before symptoms manifest.

• Family Planning: Understand potential genetic risks for offspring.

• Informed Decisions: Make proactive lifestyle and dietary choices.

• Peace of Mind: Rule out genetic predisposition with high accuracy.

Genetic testing serves as a valuable tool in the comprehensive assessment of celiac disease risk, especially for individuals with a family history or related autoimmune conditions.

Take the First Step Towards Informed Health

Empower yourself with knowledge about your genetic risk for celiac disease. The GlutenID® Celiac Genetic Home Test offers a reliable, convenient, and non-invasive method to gain insights into your health.

Order your GlutenID® test kit today and take a proactive step towards understanding your health.