Do You Know Your Gluten ID?TM
We all have one. Your Gluten ID can tell you your unique genetic susceptibility to develop Gluten Intolerance Disorder.
The severity of our body’s response to gluten consumption is best understood as a spectrum rather than a binary. While the disorder known as Celiac Disease Is this response in its most severe form, symptoms can present in more ways than commonly recognized.
What Do You Mean By Spectrum of Risk?
Gluten intolerance manifests differently in every person based on the presence or absence of two specific genes found in approximately 30%-40% of the general population.
These genes, direct the immune system to recognize gluten proteins as foreign invaders and mount a harmful inflammatory response.
Targeted Genomics organizes these unique genetic profiles into “Gluten IDs” and presents the information in an illustrative and actionable format that allows you to see your place on the Gluten Intolerance spectrum.
Where DQ2 and DQ8 are present there is potential for an immune response if the body comes in contact with gluten. The size and severity of this response is heavily influenced by coincidental genetic and environmental factors.
Targeted Genomics testing places individuals on a spectrum based on the unique combinations with which these alleles present themselves in the genome. These results can be used both to guide individual treatment and predict potential risk in family members.
Does Gluten Intolerance Disorder run in families?
Absolutely. The presence of any combination of celiac associated alleles in an individual’s genome indicates an inherited genotype predisposed to gluten intolerance.
Absence of these alleles carries a negative predictive value greater than 90%, enough to rule out a diagnosis of celiac disease. These results provide an alternative to invasive procedures such as small bowel biopsies.
Asymptomatic individuals can still carry these genes and pass them on to family members.
So if I am positive my family memebers may also be predisposed?
Yes. Even asymptomatic individuals can pass these genes on to their children. Targeted Genomics’ Gluten ID test results include a Family Relevance page placing results in a familial context with recommendations for further testing.
The Gluten ID is a non-invasive DNA-based test designed to provide:
• HLA-DR/DQ genetic susceptibility to develop gluten intolerance disorder.
• User friendly DNA-sampling from a cheek swab
• Interpretable and actionable results
• Fast turn around time